From Blurry to 4K DNA: Dante Omics AI, Rockefeller University, Giunta Lab and Global Partners Assemble the Most Complete Genome for the RPE-1 Cell Line – the Standard for Complex Cell Engineering Experiments

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NEW YORK--(BUSINESS WIRE)--Oct 3, 2025--

Dante Omics AI, Rockefeller University, Giunta Lab, Sapienza University, University of Tennessee, Trieste Area Science Park and University of L’Aquila published the successful assembly of a near-complete human diploid reference genome for one of the world’s most widely used cell lines.

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Dante Labs Diploid Genome

This breakthrough provides a reference-quality blueprint of the RPE-1 cell line, a workhorse in laboratories around the globe. Dante Omics leveraged its expertise with the Dante Labs genome sequencing test and then partnered with top tier global researchers for this project.

“Imagine trying to debug software when the source code is missing critical lines,” says Andrea Riposati, CEO of Dante Omics AI. “Now we have a precise source code for RPE-1 cells—down to the most complex, previously hidden regions of DNA like centromeres. This new reference genome is a game changer for all biotech firms advancing cell engineering and CRISPR gene editing.”

The RPE-1 line is not just any cell line — it’s one of the top three most used in cellular and molecular biology experiments worldwide, powering discoveries in genetics, cancer research, and drug development. By building the first high-accuracy, fully phased diploid genome for RPE-1, the team has leveraged short reads and long reads sequencing including PacBio and Oxford Nanopore technologies.

“We thank the Giunta Lab and our partners for this exciting project,” says Andrea Riposati.

The RPE1v1.1 assembly is publicly available through NCBI and the UCSC Genome Browser, ensuring open access for researchers worldwide.

The full paper was published on Nature Communications: https://www.nature.com/articles/s41467-025-62428-z

More information at: danteomics.com

About Dante Omics AI

We are a leading provider of AI-powered genomics solutions, dedicated to accelerating discovery and improving patient outcomes through advanced computational biology tools. The company's innovative platform combines cutting-edge artificial intelligence with high-performance computing to deliver transformative genomic analysis capabilities for research institutions, clinical laboratories, and biotechnology companies worldwide.

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SOURCE: Dante Omics AI

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PUB: 10/03/2025 06:14 AM/DISC: 10/03/2025 06:14 AM

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